mouse anti human sox10 ab Search Results


mouse anti sox10  (R&D Systems)
92
R&D Systems mouse anti sox10
Functional impacts of a HSCR-associated SNP (rs2435357) and the deletion of a novel S-HSCR enhancer on RET expression. ( a ) ATAC-seq and ChIP-seq profiles of hPSC and hNC in the intron 1 of RET show that rs2435357 is residing in a hNC-specific ATAC-seq peak. ( b ) Location of rs2435357 in the RET gene locus and in the sgRNA used for CRISPR/Cas9-mediated HDR for editing the C allele to the HSCR-associated risk allele T . The electrographs of Sanger sequencing show the successful introduction of the risk allele at rs2435357 in the UE-rs2435357 hPSC line. ( c ) Differentiation strategy to generate human neural crest (hNC) and neuronal progenitor (hNP), and immunostaining of <t>SOX10</t> and TUJ1 in hNC and hNP of the control and the mutant (UE-rs2435357) lines. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. RT-qPCR analysis showing the comparable ELAVL4 expression level in hNP in the control ( n =5) and the mutant (UE-rs2435357) ( n =3) lines. t- test, ns : not significant. ( d ) RT-qPCR analysis showing RET expression in the hPSC and hNP stages of the control ( n =5) and the mutant (UE-rs2435357) ( n =3). t- test, ns : not significant. ( e ) Publicly available Hi-C data from GM12878 cells are shown using the RET locus as anchor. The putative enhancer in intron 1 of RASGEF1A is marked in yellow. ( f ) ATAC-seq and ChIP-seq data from hPSC and hNC at the RASGEF1A intron 1 locus. ( g ) The design of sgRNAs used for the CRISPR/Cas9 system for deleting the DNA fragment in RASGEF1A intron 1. Genotyping reveals the specific deletion of RASGEF1A intron 1 in UE-RASGEF1A-int1-KO hPSC line. WT: wildtype; KO: knockout. ( h ) Immunostaining of SOX10, TUJ1 and HU in hNC and hNP of the control and the mutant (UE-rs2435357) lines, respectively. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. ( i ) RT-qPCR reveals the expression level of RET in the hPSC and hNP stages of the control ( n =4-5) and the mutant (RASGEF1A-int1-KO) ( n =6-7). t- test, ns : not significant.
Mouse Anti Sox10, supplied by R&D Systems, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 92 stars, based on 1 article reviews
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fitc sox10 mouse anti human  (Novus Biologicals)
94
Novus Biologicals fitc sox10 mouse anti human
Functional impacts of a HSCR-associated SNP (rs2435357) and the deletion of a novel S-HSCR enhancer on RET expression. ( a ) ATAC-seq and ChIP-seq profiles of hPSC and hNC in the intron 1 of RET show that rs2435357 is residing in a hNC-specific ATAC-seq peak. ( b ) Location of rs2435357 in the RET gene locus and in the sgRNA used for CRISPR/Cas9-mediated HDR for editing the C allele to the HSCR-associated risk allele T . The electrographs of Sanger sequencing show the successful introduction of the risk allele at rs2435357 in the UE-rs2435357 hPSC line. ( c ) Differentiation strategy to generate human neural crest (hNC) and neuronal progenitor (hNP), and immunostaining of <t>SOX10</t> and TUJ1 in hNC and hNP of the control and the mutant (UE-rs2435357) lines. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. RT-qPCR analysis showing the comparable ELAVL4 expression level in hNP in the control ( n =5) and the mutant (UE-rs2435357) ( n =3) lines. t- test, ns : not significant. ( d ) RT-qPCR analysis showing RET expression in the hPSC and hNP stages of the control ( n =5) and the mutant (UE-rs2435357) ( n =3). t- test, ns : not significant. ( e ) Publicly available Hi-C data from GM12878 cells are shown using the RET locus as anchor. The putative enhancer in intron 1 of RASGEF1A is marked in yellow. ( f ) ATAC-seq and ChIP-seq data from hPSC and hNC at the RASGEF1A intron 1 locus. ( g ) The design of sgRNAs used for the CRISPR/Cas9 system for deleting the DNA fragment in RASGEF1A intron 1. Genotyping reveals the specific deletion of RASGEF1A intron 1 in UE-RASGEF1A-int1-KO hPSC line. WT: wildtype; KO: knockout. ( h ) Immunostaining of SOX10, TUJ1 and HU in hNC and hNP of the control and the mutant (UE-rs2435357) lines, respectively. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. ( i ) RT-qPCR reveals the expression level of RET in the hPSC and hNP stages of the control ( n =4-5) and the mutant (RASGEF1A-int1-KO) ( n =6-7). t- test, ns : not significant.
Fitc Sox10 Mouse Anti Human, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
fitc sox10 mouse anti human - by Bioz Stars, 2026-03
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mouse testis cdna library  (OriGene)
99
OriGene mouse testis cdna library
Functional impacts of a HSCR-associated SNP (rs2435357) and the deletion of a novel S-HSCR enhancer on RET expression. ( a ) ATAC-seq and ChIP-seq profiles of hPSC and hNC in the intron 1 of RET show that rs2435357 is residing in a hNC-specific ATAC-seq peak. ( b ) Location of rs2435357 in the RET gene locus and in the sgRNA used for CRISPR/Cas9-mediated HDR for editing the C allele to the HSCR-associated risk allele T . The electrographs of Sanger sequencing show the successful introduction of the risk allele at rs2435357 in the UE-rs2435357 hPSC line. ( c ) Differentiation strategy to generate human neural crest (hNC) and neuronal progenitor (hNP), and immunostaining of <t>SOX10</t> and TUJ1 in hNC and hNP of the control and the mutant (UE-rs2435357) lines. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. RT-qPCR analysis showing the comparable ELAVL4 expression level in hNP in the control ( n =5) and the mutant (UE-rs2435357) ( n =3) lines. t- test, ns : not significant. ( d ) RT-qPCR analysis showing RET expression in the hPSC and hNP stages of the control ( n =5) and the mutant (UE-rs2435357) ( n =3). t- test, ns : not significant. ( e ) Publicly available Hi-C data from GM12878 cells are shown using the RET locus as anchor. The putative enhancer in intron 1 of RASGEF1A is marked in yellow. ( f ) ATAC-seq and ChIP-seq data from hPSC and hNC at the RASGEF1A intron 1 locus. ( g ) The design of sgRNAs used for the CRISPR/Cas9 system for deleting the DNA fragment in RASGEF1A intron 1. Genotyping reveals the specific deletion of RASGEF1A intron 1 in UE-RASGEF1A-int1-KO hPSC line. WT: wildtype; KO: knockout. ( h ) Immunostaining of SOX10, TUJ1 and HU in hNC and hNP of the control and the mutant (UE-rs2435357) lines, respectively. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. ( i ) RT-qPCR reveals the expression level of RET in the hPSC and hNP stages of the control ( n =4-5) and the mutant (RASGEF1A-int1-KO) ( n =6-7). t- test, ns : not significant.
Mouse Testis Cdna Library, supplied by OriGene, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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antibodies against sox10  (R&D Systems)
96
R&D Systems antibodies against sox10
Functional impacts of a HSCR-associated SNP (rs2435357) and the deletion of a novel S-HSCR enhancer on RET expression. ( a ) ATAC-seq and ChIP-seq profiles of hPSC and hNC in the intron 1 of RET show that rs2435357 is residing in a hNC-specific ATAC-seq peak. ( b ) Location of rs2435357 in the RET gene locus and in the sgRNA used for CRISPR/Cas9-mediated HDR for editing the C allele to the HSCR-associated risk allele T . The electrographs of Sanger sequencing show the successful introduction of the risk allele at rs2435357 in the UE-rs2435357 hPSC line. ( c ) Differentiation strategy to generate human neural crest (hNC) and neuronal progenitor (hNP), and immunostaining of <t>SOX10</t> and TUJ1 in hNC and hNP of the control and the mutant (UE-rs2435357) lines. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. RT-qPCR analysis showing the comparable ELAVL4 expression level in hNP in the control ( n =5) and the mutant (UE-rs2435357) ( n =3) lines. t- test, ns : not significant. ( d ) RT-qPCR analysis showing RET expression in the hPSC and hNP stages of the control ( n =5) and the mutant (UE-rs2435357) ( n =3). t- test, ns : not significant. ( e ) Publicly available Hi-C data from GM12878 cells are shown using the RET locus as anchor. The putative enhancer in intron 1 of RASGEF1A is marked in yellow. ( f ) ATAC-seq and ChIP-seq data from hPSC and hNC at the RASGEF1A intron 1 locus. ( g ) The design of sgRNAs used for the CRISPR/Cas9 system for deleting the DNA fragment in RASGEF1A intron 1. Genotyping reveals the specific deletion of RASGEF1A intron 1 in UE-RASGEF1A-int1-KO hPSC line. WT: wildtype; KO: knockout. ( h ) Immunostaining of SOX10, TUJ1 and HU in hNC and hNP of the control and the mutant (UE-rs2435357) lines, respectively. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. ( i ) RT-qPCR reveals the expression level of RET in the hPSC and hNP stages of the control ( n =4-5) and the mutant (RASGEF1A-int1-KO) ( n =6-7). t- test, ns : not significant.
Antibodies Against Sox10, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 96 stars, based on 1 article reviews
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mouse anti human sox10 ab  (Proteintech)
95
Proteintech mouse anti human sox10 ab
Functional impacts of a HSCR-associated SNP (rs2435357) and the deletion of a novel S-HSCR enhancer on RET expression. ( a ) ATAC-seq and ChIP-seq profiles of hPSC and hNC in the intron 1 of RET show that rs2435357 is residing in a hNC-specific ATAC-seq peak. ( b ) Location of rs2435357 in the RET gene locus and in the sgRNA used for CRISPR/Cas9-mediated HDR for editing the C allele to the HSCR-associated risk allele T . The electrographs of Sanger sequencing show the successful introduction of the risk allele at rs2435357 in the UE-rs2435357 hPSC line. ( c ) Differentiation strategy to generate human neural crest (hNC) and neuronal progenitor (hNP), and immunostaining of <t>SOX10</t> and TUJ1 in hNC and hNP of the control and the mutant (UE-rs2435357) lines. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. RT-qPCR analysis showing the comparable ELAVL4 expression level in hNP in the control ( n =5) and the mutant (UE-rs2435357) ( n =3) lines. t- test, ns : not significant. ( d ) RT-qPCR analysis showing RET expression in the hPSC and hNP stages of the control ( n =5) and the mutant (UE-rs2435357) ( n =3). t- test, ns : not significant. ( e ) Publicly available Hi-C data from GM12878 cells are shown using the RET locus as anchor. The putative enhancer in intron 1 of RASGEF1A is marked in yellow. ( f ) ATAC-seq and ChIP-seq data from hPSC and hNC at the RASGEF1A intron 1 locus. ( g ) The design of sgRNAs used for the CRISPR/Cas9 system for deleting the DNA fragment in RASGEF1A intron 1. Genotyping reveals the specific deletion of RASGEF1A intron 1 in UE-RASGEF1A-int1-KO hPSC line. WT: wildtype; KO: knockout. ( h ) Immunostaining of SOX10, TUJ1 and HU in hNC and hNP of the control and the mutant (UE-rs2435357) lines, respectively. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. ( i ) RT-qPCR reveals the expression level of RET in the hPSC and hNP stages of the control ( n =4-5) and the mutant (RASGEF1A-int1-KO) ( n =6-7). t- test, ns : not significant.
Mouse Anti Human Sox10 Ab, supplied by Proteintech, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti sox10  (R&D Systems)
92
R&D Systems anti sox10
Functional impacts of a HSCR-associated SNP (rs2435357) and the deletion of a novel S-HSCR enhancer on RET expression. ( a ) ATAC-seq and ChIP-seq profiles of hPSC and hNC in the intron 1 of RET show that rs2435357 is residing in a hNC-specific ATAC-seq peak. ( b ) Location of rs2435357 in the RET gene locus and in the sgRNA used for CRISPR/Cas9-mediated HDR for editing the C allele to the HSCR-associated risk allele T . The electrographs of Sanger sequencing show the successful introduction of the risk allele at rs2435357 in the UE-rs2435357 hPSC line. ( c ) Differentiation strategy to generate human neural crest (hNC) and neuronal progenitor (hNP), and immunostaining of <t>SOX10</t> and TUJ1 in hNC and hNP of the control and the mutant (UE-rs2435357) lines. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. RT-qPCR analysis showing the comparable ELAVL4 expression level in hNP in the control ( n =5) and the mutant (UE-rs2435357) ( n =3) lines. t- test, ns : not significant. ( d ) RT-qPCR analysis showing RET expression in the hPSC and hNP stages of the control ( n =5) and the mutant (UE-rs2435357) ( n =3). t- test, ns : not significant. ( e ) Publicly available Hi-C data from GM12878 cells are shown using the RET locus as anchor. The putative enhancer in intron 1 of RASGEF1A is marked in yellow. ( f ) ATAC-seq and ChIP-seq data from hPSC and hNC at the RASGEF1A intron 1 locus. ( g ) The design of sgRNAs used for the CRISPR/Cas9 system for deleting the DNA fragment in RASGEF1A intron 1. Genotyping reveals the specific deletion of RASGEF1A intron 1 in UE-RASGEF1A-int1-KO hPSC line. WT: wildtype; KO: knockout. ( h ) Immunostaining of SOX10, TUJ1 and HU in hNC and hNP of the control and the mutant (UE-rs2435357) lines, respectively. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. ( i ) RT-qPCR reveals the expression level of RET in the hPSC and hNP stages of the control ( n =4-5) and the mutant (RASGEF1A-int1-KO) ( n =6-7). t- test, ns : not significant.
Anti Sox10, supplied by R&D Systems, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti sox10/product/R&D Systems
Average 92 stars, based on 1 article reviews
anti sox10 - by Bioz Stars, 2026-03
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guinea pig anti sox10  (R&D Systems)
99
R&D Systems guinea pig anti sox10
Functional impacts of a HSCR-associated SNP (rs2435357) and the deletion of a novel S-HSCR enhancer on RET expression. ( a ) ATAC-seq and ChIP-seq profiles of hPSC and hNC in the intron 1 of RET show that rs2435357 is residing in a hNC-specific ATAC-seq peak. ( b ) Location of rs2435357 in the RET gene locus and in the sgRNA used for CRISPR/Cas9-mediated HDR for editing the C allele to the HSCR-associated risk allele T . The electrographs of Sanger sequencing show the successful introduction of the risk allele at rs2435357 in the UE-rs2435357 hPSC line. ( c ) Differentiation strategy to generate human neural crest (hNC) and neuronal progenitor (hNP), and immunostaining of <t>SOX10</t> and TUJ1 in hNC and hNP of the control and the mutant (UE-rs2435357) lines. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. RT-qPCR analysis showing the comparable ELAVL4 expression level in hNP in the control ( n =5) and the mutant (UE-rs2435357) ( n =3) lines. t- test, ns : not significant. ( d ) RT-qPCR analysis showing RET expression in the hPSC and hNP stages of the control ( n =5) and the mutant (UE-rs2435357) ( n =3). t- test, ns : not significant. ( e ) Publicly available Hi-C data from GM12878 cells are shown using the RET locus as anchor. The putative enhancer in intron 1 of RASGEF1A is marked in yellow. ( f ) ATAC-seq and ChIP-seq data from hPSC and hNC at the RASGEF1A intron 1 locus. ( g ) The design of sgRNAs used for the CRISPR/Cas9 system for deleting the DNA fragment in RASGEF1A intron 1. Genotyping reveals the specific deletion of RASGEF1A intron 1 in UE-RASGEF1A-int1-KO hPSC line. WT: wildtype; KO: knockout. ( h ) Immunostaining of SOX10, TUJ1 and HU in hNC and hNP of the control and the mutant (UE-rs2435357) lines, respectively. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. ( i ) RT-qPCR reveals the expression level of RET in the hPSC and hNP stages of the control ( n =4-5) and the mutant (RASGEF1A-int1-KO) ( n =6-7). t- test, ns : not significant.
Guinea Pig Anti Sox10, supplied by R&D Systems, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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myc-tagged mouse sun1 encoding 913 amino acids (nm_024451)  (OriGene)
90
OriGene myc-tagged mouse sun1 encoding 913 amino acids (nm_024451)
Functional impacts of a HSCR-associated SNP (rs2435357) and the deletion of a novel S-HSCR enhancer on RET expression. ( a ) ATAC-seq and ChIP-seq profiles of hPSC and hNC in the intron 1 of RET show that rs2435357 is residing in a hNC-specific ATAC-seq peak. ( b ) Location of rs2435357 in the RET gene locus and in the sgRNA used for CRISPR/Cas9-mediated HDR for editing the C allele to the HSCR-associated risk allele T . The electrographs of Sanger sequencing show the successful introduction of the risk allele at rs2435357 in the UE-rs2435357 hPSC line. ( c ) Differentiation strategy to generate human neural crest (hNC) and neuronal progenitor (hNP), and immunostaining of <t>SOX10</t> and TUJ1 in hNC and hNP of the control and the mutant (UE-rs2435357) lines. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. RT-qPCR analysis showing the comparable ELAVL4 expression level in hNP in the control ( n =5) and the mutant (UE-rs2435357) ( n =3) lines. t- test, ns : not significant. ( d ) RT-qPCR analysis showing RET expression in the hPSC and hNP stages of the control ( n =5) and the mutant (UE-rs2435357) ( n =3). t- test, ns : not significant. ( e ) Publicly available Hi-C data from GM12878 cells are shown using the RET locus as anchor. The putative enhancer in intron 1 of RASGEF1A is marked in yellow. ( f ) ATAC-seq and ChIP-seq data from hPSC and hNC at the RASGEF1A intron 1 locus. ( g ) The design of sgRNAs used for the CRISPR/Cas9 system for deleting the DNA fragment in RASGEF1A intron 1. Genotyping reveals the specific deletion of RASGEF1A intron 1 in UE-RASGEF1A-int1-KO hPSC line. WT: wildtype; KO: knockout. ( h ) Immunostaining of SOX10, TUJ1 and HU in hNC and hNP of the control and the mutant (UE-rs2435357) lines, respectively. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. ( i ) RT-qPCR reveals the expression level of RET in the hPSC and hNP stages of the control ( n =4-5) and the mutant (RASGEF1A-int1-KO) ( n =6-7). t- test, ns : not significant.
Myc Tagged Mouse Sun1 Encoding 913 Amino Acids (Nm 024451), supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sox10  (R&D Systems)
96
R&D Systems sox10
Functional impacts of a HSCR-associated SNP (rs2435357) and the deletion of a novel S-HSCR enhancer on RET expression. ( a ) ATAC-seq and ChIP-seq profiles of hPSC and hNC in the intron 1 of RET show that rs2435357 is residing in a hNC-specific ATAC-seq peak. ( b ) Location of rs2435357 in the RET gene locus and in the sgRNA used for CRISPR/Cas9-mediated HDR for editing the C allele to the HSCR-associated risk allele T . The electrographs of Sanger sequencing show the successful introduction of the risk allele at rs2435357 in the UE-rs2435357 hPSC line. ( c ) Differentiation strategy to generate human neural crest (hNC) and neuronal progenitor (hNP), and immunostaining of <t>SOX10</t> and TUJ1 in hNC and hNP of the control and the mutant (UE-rs2435357) lines. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. RT-qPCR analysis showing the comparable ELAVL4 expression level in hNP in the control ( n =5) and the mutant (UE-rs2435357) ( n =3) lines. t- test, ns : not significant. ( d ) RT-qPCR analysis showing RET expression in the hPSC and hNP stages of the control ( n =5) and the mutant (UE-rs2435357) ( n =3). t- test, ns : not significant. ( e ) Publicly available Hi-C data from GM12878 cells are shown using the RET locus as anchor. The putative enhancer in intron 1 of RASGEF1A is marked in yellow. ( f ) ATAC-seq and ChIP-seq data from hPSC and hNC at the RASGEF1A intron 1 locus. ( g ) The design of sgRNAs used for the CRISPR/Cas9 system for deleting the DNA fragment in RASGEF1A intron 1. Genotyping reveals the specific deletion of RASGEF1A intron 1 in UE-RASGEF1A-int1-KO hPSC line. WT: wildtype; KO: knockout. ( h ) Immunostaining of SOX10, TUJ1 and HU in hNC and hNP of the control and the mutant (UE-rs2435357) lines, respectively. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. ( i ) RT-qPCR reveals the expression level of RET in the hPSC and hNP stages of the control ( n =4-5) and the mutant (RASGEF1A-int1-KO) ( n =6-7). t- test, ns : not significant.
Sox10, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rabbit polyclonal  (Bioss)
90
Bioss rabbit polyclonal
Antibodies applied
Rabbit Polyclonal, supplied by Bioss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mouse skin  (Santa Cruz Biotechnology)
96
Santa Cruz Biotechnology mouse skin
Antibodies applied
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primary antibody staining  (Bio-Techne corporation)
99
Bio-Techne corporation primary antibody staining
Antibodies applied
Primary Antibody Staining, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Functional impacts of a HSCR-associated SNP (rs2435357) and the deletion of a novel S-HSCR enhancer on RET expression. ( a ) ATAC-seq and ChIP-seq profiles of hPSC and hNC in the intron 1 of RET show that rs2435357 is residing in a hNC-specific ATAC-seq peak. ( b ) Location of rs2435357 in the RET gene locus and in the sgRNA used for CRISPR/Cas9-mediated HDR for editing the C allele to the HSCR-associated risk allele T . The electrographs of Sanger sequencing show the successful introduction of the risk allele at rs2435357 in the UE-rs2435357 hPSC line. ( c ) Differentiation strategy to generate human neural crest (hNC) and neuronal progenitor (hNP), and immunostaining of SOX10 and TUJ1 in hNC and hNP of the control and the mutant (UE-rs2435357) lines. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. RT-qPCR analysis showing the comparable ELAVL4 expression level in hNP in the control ( n =5) and the mutant (UE-rs2435357) ( n =3) lines. t- test, ns : not significant. ( d ) RT-qPCR analysis showing RET expression in the hPSC and hNP stages of the control ( n =5) and the mutant (UE-rs2435357) ( n =3). t- test, ns : not significant. ( e ) Publicly available Hi-C data from GM12878 cells are shown using the RET locus as anchor. The putative enhancer in intron 1 of RASGEF1A is marked in yellow. ( f ) ATAC-seq and ChIP-seq data from hPSC and hNC at the RASGEF1A intron 1 locus. ( g ) The design of sgRNAs used for the CRISPR/Cas9 system for deleting the DNA fragment in RASGEF1A intron 1. Genotyping reveals the specific deletion of RASGEF1A intron 1 in UE-RASGEF1A-int1-KO hPSC line. WT: wildtype; KO: knockout. ( h ) Immunostaining of SOX10, TUJ1 and HU in hNC and hNP of the control and the mutant (UE-rs2435357) lines, respectively. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. ( i ) RT-qPCR reveals the expression level of RET in the hPSC and hNP stages of the control ( n =4-5) and the mutant (RASGEF1A-int1-KO) ( n =6-7). t- test, ns : not significant.

Journal: bioRxiv

Article Title: Whole-genome analysis of noncoding genetic variations identifies multigranular regulatory element perturbations associated with Hirschsprung disease

doi: 10.1101/2020.04.08.032045

Figure Lengend Snippet: Functional impacts of a HSCR-associated SNP (rs2435357) and the deletion of a novel S-HSCR enhancer on RET expression. ( a ) ATAC-seq and ChIP-seq profiles of hPSC and hNC in the intron 1 of RET show that rs2435357 is residing in a hNC-specific ATAC-seq peak. ( b ) Location of rs2435357 in the RET gene locus and in the sgRNA used for CRISPR/Cas9-mediated HDR for editing the C allele to the HSCR-associated risk allele T . The electrographs of Sanger sequencing show the successful introduction of the risk allele at rs2435357 in the UE-rs2435357 hPSC line. ( c ) Differentiation strategy to generate human neural crest (hNC) and neuronal progenitor (hNP), and immunostaining of SOX10 and TUJ1 in hNC and hNP of the control and the mutant (UE-rs2435357) lines. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. RT-qPCR analysis showing the comparable ELAVL4 expression level in hNP in the control ( n =5) and the mutant (UE-rs2435357) ( n =3) lines. t- test, ns : not significant. ( d ) RT-qPCR analysis showing RET expression in the hPSC and hNP stages of the control ( n =5) and the mutant (UE-rs2435357) ( n =3). t- test, ns : not significant. ( e ) Publicly available Hi-C data from GM12878 cells are shown using the RET locus as anchor. The putative enhancer in intron 1 of RASGEF1A is marked in yellow. ( f ) ATAC-seq and ChIP-seq data from hPSC and hNC at the RASGEF1A intron 1 locus. ( g ) The design of sgRNAs used for the CRISPR/Cas9 system for deleting the DNA fragment in RASGEF1A intron 1. Genotyping reveals the specific deletion of RASGEF1A intron 1 in UE-RASGEF1A-int1-KO hPSC line. WT: wildtype; KO: knockout. ( h ) Immunostaining of SOX10, TUJ1 and HU in hNC and hNP of the control and the mutant (UE-rs2435357) lines, respectively. Scale bars: (hNC): 100 μ m; (hNP): 200 μ m. ( i ) RT-qPCR reveals the expression level of RET in the hPSC and hNP stages of the control ( n =4-5) and the mutant (RASGEF1A-int1-KO) ( n =6-7). t- test, ns : not significant.

Article Snippet: Fixed cells were blocked with blocking solution (1% BSA, 0.1% Triton X-100 in PBS) at room temperature for 1 h. The blocked cells were then incubated with primary antibodies (mouse anti-SOX10 (1:500, R&D Systems, MAB2864), rabbit anti-TUJ1 (1:1000, Abcam, ab18207) and mouse anti-HU (1:1000, Life Technologies, #A-21271) at 4 °C for 1 overnight.

Techniques: Functional Assay, Expressing, ChIP-sequencing, CRISPR, Sequencing, Immunostaining, Mutagenesis, Quantitative RT-PCR, Hi-C, Knock-Out

Antibodies applied

Journal: Hearing research

Article Title: Culture media-based selection of endothelial cells, pericytes, and perivascular-resident macrophage-like melanocytes from the young mouse vestibular system

doi: 10.1016/j.heares.2016.12.012

Figure Lengend Snippet: Antibodies applied

Article Snippet: SOX10 , BiossInc, Woburn, MA , Cat# Bs-6449R , 1:50 , Rabbit polyclonal , Human, Mouse, Rat, Bovine.

Techniques: